FITC标记的人乙型肝炎表面抗原单克隆抗体（检测）
产品名称： FITC标记的人乙型肝炎表面抗原单克隆抗体（检测）
英文名称： Anti-HBsAg(H2F4)/FITC
产品编号： HZ-2024M-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Mouse Anti-HBsAg(H2F4)/FITC Conjugated antibody
FITC标记的人乙型肝炎表面抗原单克隆抗体（检测）
| 英文名称 | Anti-HBsAg(H2F4)/FITC |
| 中文名称 | FITC标记的人乙型肝炎表面抗原单克隆抗体（检测） |
| 别 名 | Hepatitis B Virus Surface Antigen; HBsAg; HBV major surface antigen; HBV surface antigen; Hepatitis B Virus major surface antigen; Major surface antigen; S; HBSAG_HBVC5. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 免疫学 细菌及病毒 |
| 抗体来源 | Mouse |
| 克隆类型 | Monoclonal |
| 克 隆 号 | H2F4 |
| 交叉反应 | HBsAg |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 44kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | Human Hepatitis B Surface Antigen protein |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Hepatitis B Virus Surface Antigen, Hepatitis B Virus (HBV) infection induces a disease state characterised by liver damage, inflammation and viral persistence. Infection also increases the risk of hepatocellular carcinoma. HBV belongs to the Hepadnaviridae family of viruses. Its genome consists of partially double stranded circular DNA. The DNA is enclosed in a nucleocapsid, or core antigen (HBcAg), which is surrounded by a spherical envelope (surface antigen or HBsAg). The core antigen shares its sequences with the e antigen (HBeAg) but no cross reactivity between the two proteins has been observed. The HBV genome also encodes a DNA polymerase that also acts as a reverse transcriptase. Function: The large envelope protein exists in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assumes fusion between virion membrane and endosomal membrane (Probable). In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein. The middle envelope protein plays an important role in the budding of the virion. It is involved in the induction of budding in a nucleocapsid independent way. In this process the majority of envelope proteins bud to form subviral lipoprotein particles of 22 nm of diameter that do not contain a nucleocapsid. Subunit: Li-HBsAg interacts with capsid protein and with HDV Large delta antigen. Isoform M associates with host chaperone CANX through its pre-S2 N glycan. This association may be essential for M proper secretion. Subcellular Location: Virion membrane. Post-translational modifications: Isoform M is N-terminaly acetylated at a ratio of 90%, and N-glycosylated at the pre-S2 region. Myristoylated. Similarity: Belongs to the orthohepadnavirus major surface antigen family. Database links: Entrez Gene: 2828293 Hepatitis B virus Entrez Gene: 944569 Hepatitis B virus SwissProt: P03138 Hepatitis B virus SwissProt: P03140 Hepatitis B virus SwissProt: P03141 Hepatitis B virus SwissProt: Q81157 Hepatitis B virus SwissProt: Q81158 Hepatitis B virus SwissProt: Q81159 Hepatitis B virus SwissProt: Q81160 Hepatitis B virus Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 人乙型肝炎表面抗原抗体 |
乙型肝炎病毒表面抗原、乙型肝炎病毒（HBV）感染可诱发以肝损伤、炎症和病毒持续为特征的疾病状态。感染也会增加肝细胞癌的风险。HBV属于Hepadnaviridae氏病毒家族。其基因组由部分双链环状DNA组成。DNA被包裹在核衣壳或核心抗原（HBcAg）中，核心抗原被球形的包膜（表面抗原或HBsAg）包围。核心抗原与e抗原（HBeAg）共享其序列，但是没有观察到两种蛋白之间的交叉反应。HBV基因组也编码一种DNA聚合酶，它也起反转录酶的作用。