FITC标记的锚蛋白重复结构域蛋白20A3抗体
产品名称： FITC标记的锚蛋白重复结构域蛋白20A3抗体
英文名称： Anti-ANKRD20A3/FITC
产品编号： HZ-9747R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-ANKRD20A3/FITC Conjugated antibody
FITC标记的锚蛋白重复结构域蛋白20A3抗体
| 产品编号 | bs-9747R-FITC |
| 英文名称 | Anti-ANKRD20A3/FITC |
| 中文名称 | FITC标记的锚蛋白重复结构域蛋白20A3抗体 |
| 别 名 | Ankyrin repeat domain 20 family member A3; Ankyrin repeat domain 20A related; Ankyrin repeat domain containing protein 20A3; MGC176486; MGC198508; A20A3_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 94kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ANKRD20A3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Ankyrins are membrane adaptor molecules that play important roles in coupling integral membrane proteins to the spectrin-based cytoskeleton network. Mutations of ankyrin genes lead to severe genetic diseases such as fatal cardiac arrhythmias and hereditary spherocytosis. ANKRD20A (ankyrin repeat domain-containing protein 20A) is an 823 amino acid protein that contains five ANK repeats. The gene encoding ANKRD20A maps to chromosome 9, which consists of about 145 million bases and encodes nearly 900 genes. Considered to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, and familial dysautonomia are associated with chromosome 9. Also, chromosome 9 is partnered with chromosome 22 in the translocation leading to the aberrant production of BCR-ABL fusion protein often found in leukemias. Similarity: Contains 5 ANK repeats. Database links: Entrez Gene: 441425 Human SwissProt: Q5VUR7 Human Unigene: 632663 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
锚蛋白是膜结合分子，在整合膜蛋白与基于血影蛋白的细胞骨架网络中发挥重要作用。锚蛋白基因突变导致严重的遗传性疾病，如致命性心律失常和遗传性球形红细胞增多症。AKRD20A（锚蛋白重复结构域包含蛋白20A）是包含五个重复序列的823氨基酸蛋白质。编码AKRD20A的基因定位于9号染色体，由约1亿4500万个碱基组成，编码近900个基因。认为在性别决定中起作用的是，9P末端的缺失可导致男性与女性性别逆转的发展，一个具有男性X、Y基因型的女性的表型。遗传性出血性毛细血管扩张症，其特征是由有害的血管缺陷和家族性精神障碍引起的，与9号染色体有关。此外，染色体9与易位中的22号染色体相关，导致BCR-ABL融合蛋白在白血病中的异常生成。