CDKN2A polyclonal antibody (DyLight 549)-抗体-抗体-生物在线
亚诺法生技股份有限公司（Abnova)
CDKN2A polyclonal antibody (DyLight 549)

CDKN2A polyclonal antibody (DyLight 549)

商家询价

产品名称： CDKN2A polyclonal antibody (DyLight 549)

英文名称： CDKN2A polyclonal antibody (DyLight 549)

产品编号： PAB15352

产品价格： null

产品产地： 台湾

品牌商标： Abnova

更新时间： null

使用范围：

亚诺法生技股份有限公司（Abnova)
  • 联系人 :
  • 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
  • 邮编 : 11493
  • 所在区域 : 台湾
  • 电话 : +886-920**1152 点击查看
  • 传真 : 点击查看
  • 邮箱 : sales@abnova.com.tw
进入展台

  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of CDKN2A.
  • Immunogen:
  • A synthetic peptide corresponding to amino acids 100-200 of human CDKN2A.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Specificity:
  • This antibody reacts with human p14ARF. Other species have not been tested. This is specific to p14ARF. This antibody may be used for Western blotting, where a band is seen at ~16 KDa, representing p14ARF (p14ARF tends to run slightly higher than the theoretical MW of 14 KDa). Additional non-specific bands may be seen at ~25 and 47 KDa.
  • Form:
  • Liquid
  • Conjugation:
  • DyLight 549
  • Storage Buffer:
  • In 50 mM sodium borate
  • Storage Instruction:
  • Store at 4°C. Do not freeze.
  • Recommend Usage:
  • Western Blot (2 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Applications
  • Western Blot
  • Application Image
  • Western Blot
  • Gene Information
  • Entrez GeneID:
  • 1029
  • Gene Name:
  • CDKN2A
  • Gene Alias:
  • ARF,CDK4I,CDKN2,CMM2,INK4,INK4a,MLM,MTS1,TP16,p14,p14ARF,p16,p16INK4,p16INK4a,p19
  • Gene Description:
  • cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
  • Gene Summary:
  • This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq
  • Other Designations:
  • CDK4 inhibitor p16-INK4,OTTHUMP00000021147,OTTHUMP00000021148,cell cycle negative regulator beta,cyclin-dependent kinase inhibitor 2A,cyclin-dependent kinase inhibitor p16,multiple tumor suppressor 1
  • Related Disease

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