SH2D1A polyclonal antibody
产品名称： SH2D1A polyclonal antibody
英文名称： SH2D1A polyclonal antibody
产品编号： PAB6819
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Goat polyclonal antibody raised against synthetic peptide of SH2D1A.
- Immunogen:
- A synthetic peptide corresponding to human SH2D1A.
- Sequence:
- C-HKRYFRKIKN
- Host:
- Goat
- Theoretical MW (kDa):
- 14.2, 13.9
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Antigen affinity purification
- Concentration:
- 0.5 mg/mL
- Storage Buffer:
- In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- ELISA (1:16000)
Western Blot (0.3-1 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- The adaptor protein SH2D1A regulates signaling through CD150 (SLAM) in B cells.
Mikhalap SV, Shlapatska LM, Yurchenko OV, Yurchenko MY, Berdova GG, Nichols KE, Clark EA, Sidorenko SP.Blood. 2004 Dec 15;104(13):4063-70. Epub 2004 Aug 17.
- Applications
- Western Blot (Tissue lysate)
- SH2D1A polyclonal antibody (Cat # PAB6819) staining (0.3 ug/mL) of human thymus lysate (RIPA buffer, 30 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
- Entrez GeneID:
- 4068
- Protein Accession#:
- NP_002342.1
- Gene Name:
- SH2D1A
- Gene Alias:
- DSHP,EBVS,FLJ18687,FLJ92177,IMD5,LYP,MTCP1,SAP,XLP,XLPD
- Gene Description:
- SH2 domain protein 1A
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- Duncan's disease,OTTHUMP00000023976,SLAM-associated protein,T cell signal transduction molecule SAP,signaling lymphocyte activation molecule-associated protein
- Gene Pathway