SUMO3 polyclonal antibody
产品名称： SUMO3 polyclonal antibody
英文名称： SUMO3 polyclonal antibody
产品编号： PAB1859
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against full length recombinant SUMO3.
- Immunogen:
- Recombinant protein corresponding to full length human SUMO3.
- Host:
- Rabbit
- Reactivity:
- Human
- Specificity:
- This antibody recognize all 3 SUMO isoforms, including human SUMO1, SUMO2 and SUMO3.
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- SUMO promotes HDAC-mediated transcriptional repression.
Yang SH, Sharrocks AD.Mol Cell. 2004 Feb 27;13(4):611-7.
- 2.
- Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription.
Ling Y, Sankpal UT, Robertson AK, McNally JG, Karpova T, Robertson KD.Nucleic Acids Res. 2004 Jan 29;32(2):598-610. Print 2004.
- 3.
- Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1.
Bailey D, O'Hare P.J Biol Chem. 2004 Jan 2;279(1):692-703. Epub 2003 Oct 16.
- Applications
- Western Blot
- The SUMO3 polyclonal antibody (Cat # PAB1859) is used in Western blot to detect SUMO3 in GST-Sumo3 (lane 1) and 293 cell lysate (lane 2) .
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with SUMO3 polyclonal antibody (Cat # PAB1859), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
- Entrez GeneID:
- 6612
- Protein Accession#:
- AAC50996;P63165;NP_008868;P61956;NP_008867;P55854
- Gene Name:
- SUMO3
- Gene Alias:
- SMT3A,SMT3H1,SUMO-3
- Gene Description:
- SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)
- Omim ID:
- 602231
- Gene Ontology:
- Hyperlink
- Gene Summary:
- SUMO proteins, such as SUMO3, and ubiquitin (see MIM 191339) posttranslationally modify numerous cellular proteins and affect their metabolism and function. However, unlike ubiquitination, which targets proteins for degradation, sumoylation participates in a number of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability (Su and Li, 2002 [PubMed 12383504]).[supplied by OMIM
- Other Designations:
- OTTHUMP00000115275,SMT3 suppressor of mif two 3 homolog 1,small ubiquitin-like modifier protein 3