FITC标记的SH2结构域蛋白3A抗体
产品名称： FITC标记的SH2结构域蛋白3A抗体
英文名称： Anti-SH2D3A/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
上海沪震实业有限公司
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Rabbit Anti-SH2D3A/FITC Conjugated antibody
FITC标记的SH2结构域蛋白3A抗体
| 英文名称 | Anti-SH2D3A/FITC |
| 中文名称 | FITC标记的SH2结构域蛋白3A抗体 |
| 别 名 | Novel SH2 containing protein 1; NSP1; SH2 domain containing 3A; SH2 domain containing protein 3A; SH23A_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 信号转导 转录调节因子 G蛋白偶联受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Pig, Cow, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 63kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NSP1/SH2D3A |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: SH2D3A is a 576 amino acid protein that is thought to play a role in JNK activation. SH2D3A interacts with p130 Cas and is found at low levels in fetal kidney, fetal lung, placenta, adult pancreas, kidney and lung. Subject to post-translational phosphorylation on multiple tyrosine residues, SH2D3A contains one Src homology 2 (SH2) domain. SH2 domains bind to tyrosine-phosphorylated regions of target proteins, frequently linking activated growth factors to putative signal transduction proteins. The gene encoding SH2D3A maps to human chromosome 19, which consists of over 63 million bases, houses approximately 1,400 genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin (Ig) superfamily members, including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG families and Fc receptors (FcRs). Function: May play a role in JNK activation. Subunit: Interacts with BCAR1. Tissue Specificity: Weakly expressed in placenta, fetal kidney, fetal lung, adult pancreas, adult kidney and adult lung. Post-translational modifications: Phosphorylated on tyrosine. Similarity: Contains 1 SH2 domain. Database links: Entrez Gene: 10045 Human GenBank: BC006281 Human Omim: 604721 Human SwissProt: Q9BRG2 Human Unigene: 439645 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
SH 2D3A是一种被认为在JNK激活中发挥作用的576氨基酸蛋白。SH 2D3A与P130 CAS相互作用，在胎儿肾脏、胎儿肺、胎盘、胰腺、肾和肺中均处于低水平。受多个酪氨酸残基的翻译后磷酸化，SH2D3A包含一个Src同源2（SH2）结构域。SH2结构域与靶蛋白的酪氨酸磷酸化区域结合，频繁地将激活的生长因子连接到假定的信号转导蛋白。编码SH 2D3A的基因映射到人类染色体19，其由6300万多个碱基组成，约有1400个基因，并被公认为具有人类染色体最大的基因密度。它是许多免疫球蛋白（Ig）超家族成员的遗传宿主，包括杀伤细胞和白细胞Ig样受体、多个ICAMs、CEACAM和PSG家族和Fc受体（FCRS）。